Musashi-2 contributes to myotonic dystrophy muscle dysfunction by promoting excessive autophagy through miR-7 biogenesis repression

Musashi-2 contributes to myotonic dystrophy muscle dysfunction by promoting excessive autophagy through miR-7 biogenesis repression

Skeletal muscle symptoms strongly contribute to mortality of myotonic dystrophy type 1 (DM1) patients. DM1 is a neuromuscular genetic disease caused by CTG repeat expansions that, upon transcription, sequester the Muscleblind-like family of proteins and dysregulate alternative splicing of hundreds o...

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Main Authors: Maria Sabater-Arcis (Author), Ariadna Bargiela (Author), Nerea Moreno (Author), Javier Poyatos-Garcia (Author), Juan J. Vilchez (Author), Ruben Artero (Author)
Format: Book
Published: Elsevier, 2021-09-01T00:00:00Z.
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