Musashi-2 contributes to myotonic dystrophy muscle dysfunction by promoting excessive autophagy through miR-7 biogenesis repression

• Auteurs principaux: Maria Sabater-Arcis (Auteur), Ariadna Bargiela (Auteur), Nerea Moreno (Auteur), Javier Poyatos-Garcia (Auteur), Juan J. Vilchez (Auteur), Ruben Artero (Auteur)
• Format: Livre
• Publié: Elsevier, 2021-09-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Skeletal muscle symptoms strongly contribute to mortality of myotonic dystrophy type 1 (DM1) patients. DM1 is a neuromuscular genetic disease caused by CTG repeat expansions that, upon transcription, sequester the Muscleblind-like family of proteins and dysregulate alternative splicing of hundreds o...