Musashi-2 contributes to myotonic dystrophy muscle dysfunction by promoting excessive autophagy through miR-7 biogenesis repression

• Main Authors: Maria Sabater-Arcis (Author), Ariadna Bargiela (Author), Nerea Moreno (Author), Javier Poyatos-Garcia (Author), Juan J. Vilchez (Author), Ruben Artero (Author)
• Formato: Libro
• Publicado: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Skeletal muscle symptoms strongly contribute to mortality of myotonic dystrophy type 1 (DM1) patients. DM1 is a neuromuscular genetic disease caused by CTG repeat expansions that, upon transcription, sequester the Muscleblind-like family of proteins and dysregulate alternative splicing of hundreds o...