Synthesis, computational studies, tyrosinase inhibitory kinetics and antimelanogenic activity of hydroxy substituted 2-[(4-acetylphenyl)amino]-2-oxoethyl derivatives

• Main Authors: Muhammad Rafiq (Author), Yasir Nazir (Author), Zaman Ashraf (Author), Hummera Rafique (Author), Samina Afzal (Author), Amara Mumtaz (Author), Mubashir Hassan (Author), Anser Ali (Author), Khurram Afzal (Author), Muhammad Rizwan Yousuf (Author), Muhammad Saleem (Author), Katarzyna Kotwica-Mojzych (Author), Mariusz Mojzych (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The over expression of melanogenic enzymes like tyrosinase caused many hyperpigmentaion disorders. The present work describes the synthesis of hydroxy substituted 2-[(4-acetylphenyl)amino]-2-oxoethyl derivatives 3a-e and 5a-e as antimelanogenic agents. The tyrosinase inhibitory activity of synthesiz...