Inhibitors of <i>O</i>-Acetylserine Sulfhydrylase with a Cyclopropane-Carboxylic Acid Scaffold Are Effective Colistin Adjuvants in Gram Negative Bacteria

• Main Authors: Giannamaria Annunziato (Author), Costanza Spadini (Author), Marialaura Marchetti (Author), Nina Franko (Author), Marialaura Pavone (Author), Mattia Iannarelli (Author), Agostino Bruno (Author), Marco Pieroni (Author), Stefano Bettati (Author), Clotilde Silvia Cabassi (Author), Barbara Campanini (Author), Gabriele Costantino (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antibacterial adjuvants are of great significance, since they allow one to downscale the therapeutic dose of conventional antibiotics and reduce the insurgence of antibacterial resistance. Herein, we report that <i>O</i>-acetylserine sulfhydrylase (OASS) inhibitors could be used as colis...