Characterization of a splice-site mutation in the tumor suppressor gene FLCN associated with renal cancer

• Main Authors: Malte P. Bartram (Author), Tripti Mishra (Author), Nadine Reintjes (Author), Francesca Fabretti (Author), Hakam Gharbi (Author), Alexander C. Adam (Author), Heike Göbel (Author), Mareike Franke (Author), Bernhard Schermer (Author), Stefan Haneder (Author), Thomas Benzing (Author), Bodo B. Beck (Author), Roman-Ulrich Müller (Author)
• Format: Book
• Published: BMC, 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Renal cell carcinoma is among the most prevalent malignancies. It is generally sporadic. However, genetic studies of rare familial forms have led to the identification of mutations in causative genes such as VHL and FLCN. Mutations in the FLCN gene are the cause of Birt-Hogg-Dube...