Population Pharmacokinetic Analysis Proves Superiority of Continuous Infusion in PK/PD Target Attainment with Oxacillin in Staphylococcal Infections

• Päätekijät: Irena Murínová (Tekijä), Martin Švidrnoch (Tekijä), Tomáš Gucký (Tekijä), Jan Hlaváč (Tekijä), Pavel Michálek (Tekijä), Ondřej Slanař (Tekijä), Martin Šíma (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2022-12-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Considering its very short elimination half-life, the approved oxacillin dosage might not be sufficient to maintain the pharmacokinetic/pharmacodynamics (PK/PD) target of time-dependent antibiotics. This study aimed to describe the population pharmacokinetics of oxacillin and to explore the probabil...