Population Pharmacokinetic Analysis Proves Superiority of Continuous Infusion in PK/PD Target Attainment with Oxacillin in Staphylococcal Infections

• Hoofdauteurs: Irena Murínová (Auteur), Martin Švidrnoch (Auteur), Tomáš Gucký (Auteur), Jan Hlaváč (Auteur), Pavel Michálek (Auteur), Ondřej Slanař (Auteur), Martin Šíma (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2022-12-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Considering its very short elimination half-life, the approved oxacillin dosage might not be sufficient to maintain the pharmacokinetic/pharmacodynamics (PK/PD) target of time-dependent antibiotics. This study aimed to describe the population pharmacokinetics of oxacillin and to explore the probabil...