MMPP Exerts Anti-Inflammatory Effects by Suppressing MD2-Dependent NF-κB and JNK/AP-1 Pathways in THP-1 Monocytes

• Main Authors: Seonhwa Kim (Author), Na-Yeon Kim (Author), Jae-Young Park (Author), Hyo-Min Park (Author), Chae-Min Lim (Author), Jinju Kim (Author), Hee Pom Lee (Author), Jin Tae Hong (Author), Do-Young Yoon (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

(E)-2-methoxy-4-[3-(4-methoxyphenyl) prop-1-en-1-yl] phenol (MMPP), a novel synthetic analog of (E)-2,4-bis(p-hydroxyphenyl)-2-butenal (BHPB), exerts anti-inflammatory and anticancer effects by downregulating the STAT3 pathway. It has also been recently reported that MMPP can act as a PPAR agonist w...