Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export

• Main Authors: Phillip J. White (Author), Amanda L. Lapworth (Author), Jie An (Author), Liping Wang (Author), Robert W. McGarrah (Author), Robert D. Stevens (Author), Olga Ilkayeva (Author), Tabitha George (Author), Michael J. Muehlbauer (Author), James R. Bain (Author), Jeff K. Trimmer (Author), M. Julia Brosnan (Author), Timothy P. Rolph (Author), Christopher B. Newgard (Author)
• Format: Book
• Published: Elsevier, 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: A branched-chain amino acid (BCAA)-related metabolic signature is strongly associated with insulin resistance and predictive of incident diabetes and intervention outcomes. To better understand the role that this metabolite cluster plays in obesity-related metabolic dysfunction, we studie...