The Human SCN10AG1662S Point Mutation Established in Mice Impacts on Mechanical, Heat, and Cool Sensitivity

• Autores principales: Celeste Chidiac (Autor), Yaping Xue (Autor), Maria del Mar Muniz Moreno (Autor), Ameer Abu Bakr Rasheed (Autor), Romain Lorentz (Autor), Marie-Christine Birling (Autor), Claire Gaveriaux-Ruff (Autor), Yann Herault (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

The voltage-gated sodium channel NAV1.8 is expressed in primary nociceptive neurons and is involved in pain transmission. Mutations in the SCN10A gene (encoding NAV1.8 channel) have been identified in patients with idiopathic painful small fiber neuropathy (SFN) including the SCN10AG1662S gain-of-fu...