Cyclotides Isolated from an Ipecac Root Extract Antagonize the Corticotropin Releasing Factor Type 1 Receptor

• Main Authors: Mohsen Fahradpour (Author), Peter Keov (Author), Carlotta Tognola (Author), Estela Perez-Santamarina (Author), Peter J. McCormick (Author), Alireza Ghassempour (Author), Christian W. Gruber (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cyclotides are plant derived, cystine-knot stabilized peptides characterized by their natural abundance, sequence variability and structural plasticity. They are abundantly expressed in Rubiaceae, Psychotrieae in particular. Previously the cyclotide kalata B7 was identified to modulate the human oxy...