Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers

Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers

A new wave of dual Topo I/II inhibitors was designed and synthesised via the hybridisation of spirooxindoles and pyrimidines. In situ selenium nanoparticles (SeNPs) for some derivatives were synthesised. The targets and the SeNP derivatives were examined for their cytotoxicity towards five cancer ce...

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Main Authors: Samar El-Kalyoubi (Author), Mohamed M. Khalifa (Author), Mahmoud T. Abo-Elfadl (Author), Ahmed A. El-Sayed (Author), Ahmed Elkamhawy (Author), Kyeong Lee (Author), Ahmed A. Al-Karmalawy (Author)
Format: Book
Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
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