A comparison of DNA repair pathways to achieve a site-specific gene modification of the Bruton's tyrosine kinase gene

• Main Authors: David H. Gray (Author), Jasmine Santos (Author), Alexandra Grace Keir (Author), Isaac Villegas (Author), Simon Maddock (Author), Edward C. Trope (Author), Joseph D. Long (Author), Caroline Y. Kuo (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gene editing utilizing homology-directed repair has advanced significantly for many monogenic diseases of the hematopoietic system in recent years but has also been hindered by decreases between in vitro and in vivo gene integration rates. Homology-directed repair occurs primarily in the S/G2 phases...