Variable domain mutational analysis to probe the molecular mechanisms of high viscosity of an IgG1 antibody

• المؤلفون الرئيسيون: Jing Dai (مؤلف), Saeed Izadi (مؤلف), Jonathan Zarzar (مؤلف), Patrick Wu (مؤلف), Angela Oh (مؤلف), Paul J. Carter (مؤلف)
• التنسيق: كتاب
• منشور في: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

ABSTRACTSubcutaneous injection is the preferred route of administration for many antibody therapeutics for reasons that include its speed and convenience. However, the small volume limit (typically [Formula: see text]2 mL) for subcutaneous delivery often necessitates antibody formulations at high co...