Variable domain mutational analysis to probe the molecular mechanisms of high viscosity of an IgG1 antibody

• Main Authors: Jing Dai (Author), Saeed Izadi (Author), Jonathan Zarzar (Author), Patrick Wu (Author), Angela Oh (Author), Paul J. Carter (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTSubcutaneous injection is the preferred route of administration for many antibody therapeutics for reasons that include its speed and convenience. However, the small volume limit (typically [Formula: see text]2 mL) for subcutaneous delivery often necessitates antibody formulations at high co...