Cereblon-Recruiting PROTACs: Will New Drugs Have to Face Old Challenges?

• मुख्य लेखकों: Marcin Cieślak (लेखक), Marta Słowianek (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2023-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The classical low-molecular-weight drugs are designed to bind with high affinity to the biological targets endowed with receptor or enzymatic activity, and inhibit their function. However, there are many non-receptor or non-enzymatic disease proteins that seem undruggable using the traditional drug...