Improved synthesis of [18F] fallypride and characterization of a Huntington's disease mouse model, zQ175DN KI, using longitudinal PET imaging of D2/D3 receptors

• Main Authors: Tuulia Huhtala (Author), Pekka Poutiainen (Author), Jussi Rytkönen (Author), Kimmo Lehtimäki (Author), Teija Parkkari (Author), Iiris Kasanen (Author), Anu J. Airaksinen (Author), Teija Koivula (Author), Patrick Sweeney (Author), Outi Kontkanen (Author), John Wityak (Author), Celia Dominiquez (Author), Larry C. Park (Author)
• Format: Book
• Published: SpringerOpen, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Purpose Dopamine receptors are involved in pathophysiology of neuropsychiatric diseases, including Huntington's disease (HD). PET imaging of dopamine D2 receptors (D2R) in HD patients has demonstrated 40% decrease in D2R binding in striatum, and D2R could be a reliable quantitative tar...