Genetic reconstruction of protozoan rRNA decoding sites provides a rationale for paromomycin activity against Leishmania and Trypanosoma.

• Main Authors: Sven N Hobbie (Author), Marcel Kaiser (Author), Sebastian Schmidt (Author), Dmitri Shcherbakov (Author), Tanja Janusic (Author), Reto Brun (Author), Erik C Böttger (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aminoglycoside antibiotics target the ribosomal decoding A-site and are active against a broad spectrum of bacteria. These compounds bind to a highly conserved stem-loop-stem structure in helix 44 of bacterial 16S rRNA. One particular aminoglycoside, paromomycin, also shows potent antiprotozoal acti...