Validation of a radiosynthesis method and a novel quality control system for [68 Ga]Ga-MAA: is TLC enough to assess radiopharmaceutical quality?

• Main Authors: Silvia Migliari (Author), Stefano Bruno (Author), Annalisa Bianchera (Author), Ilaria De Nardis (Author), Antonio Scarano (Author), Monica Lusardi (Author), Anna Gaiani (Author), Alessandra Guercio (Author), Maura Scarlattei (Author), Giorgio Baldari (Author), Ruggero Bettini (Author), Livia Ruffini (Author)
• Format: Book
• Published: SpringerOpen, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Technetium-99 m-labelled macroaggregated human serum albumin ([99mTc]Tc-MAA) is commonly used for lung perfusion scintigraphy. The European Pharmacopoeia (Eu.Ph.) specifies thin-layer chromatography (TLC) as the only method to assess its radiochemical purity (RCP). Similarly, TLC...