Placental sFLT1 is associated with complement activation and syncytiotrophoblast damage in preeclampsia

• Main Authors: Ai-ris Yonekura Collier (Author), Zsuzsanna Zsengeller (Author), Elizabeth Pernicone (Author), Saira Salahuddin (Author), Eliyahu V. Khankin (Author), S. Ananth Karumanchi (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The immune complement system protects against pathogens; however, excess activation results in disease like hemolytic uremic syndrome, a clinical imitator of preeclampsia. Vascular endothelial factor (VEGF) protects against aberrant complement activation and is inhibited by soluble fms-like tyrosine...