LCAT protects against Lipoprotein‐X formation in a murine model of drug‐induced intrahepatic cholestasis

• Main Authors: Marcelo J. A. Amar (Author), Lita A. Freeman (Author), Takafumi Nishida (Author), Maureen L. Sampson (Author), Milton Pryor (Author), Boris L. Vaisman (Author), Edward B. Neufeld (Author), Sotirios K. Karathanasis (Author), Alan T. Remaley (Author)
• Format: Book
• Published: Wiley, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Familial lecithin:cholesterol acyltransferase (LCAT) deficiency (FLD) is a rare genetic disease characterized by low HDL‐C levels, low plasma cholesterol esterification, and the formation of Lipoprotein‐X (Lp‐X), an abnormal cholesterol‐rich lipoprotein particle. LCAT deficiency causes corn...