Notch4 activation aggravates NF-κB-mediated inflammation in HIV-1-associated nephropathy

• Principais autores: Rajni Vaid Puri (Autor), Sireesha Yerrathota (Autor), Trisha Home (Autor), Jessica Y. Idowu (Autor), V. Praveen Chakravarthi (Autor), Christopher J. Ward (Autor), Pravin C. Singhal (Autor), Gregory B. Vanden Heuvel (Autor), Timothy A. Fields (Autor), Madhulika Sharma (Autor)
• Formato: Livro
• Publicado em: The Company of Biologists, 2019-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Notch pathway activation plays a central role in the pathogenesis of many glomerular diseases. We have previously shown that Notch4 expression was upregulated in various renal cells in human immunodeficiency virus (HIV)-associated nephropathy (HIVAN) patients and rodent models of HIVAN. In this stud...