Pretomanid dose selection for pulmonary tuberculosis: An application of multi‐objective optimization to dosage regimen design

Abstract Clinical development of combination chemotherapies for tuberculosis (TB) is complicated by partial or restricted phase II dose‐finding. Barriers include a propensity for drug resistance with monotherapy, practical limits on numbers of treatment arms for component dose combinations, and limi...

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Main Author: Michael A. Lyons (Author)
Format: Book
Published: Wiley, 2021-03-01T00:00:00Z.
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3rd Floor Main Library

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