Proteomic Analysis Reveals Autophagy as Pro-Survival Pathway Elicited by Long-Term Exposure with 5-Azacitidine in High-Risk Myelodysplasia

• Main Authors: Alessandra Romano (Author), Cesarina Giallongo (Author), Piera La Cava (Author), Nunziatina L. Parrinello (Author), Antonella Chiechi (Author), Calogero Vetro (Author), Daniele Tibullo (Author), Francesco Di Raimondo (Author), Lance A. Liotta (Author), Virginia Espina (Author), Giuseppe A. Palumbo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Azacytidine (5-AZA) is the standard first-choice treatment for high-risk myelodysplasia (MDS) patients. However, the clinical outcome for those patients who interrupt treatment or whose disease failed to respond is very poor. In order to identify the cellular pathways that are modified by long-term...