Anti-Cancer Effects of 3, 3'-Diindolylmethane on Human Hepatocellular Carcinoma Cells Is Enhanced by Calcium Ionophore: The Role of Cytosolic Ca2+ and p38 MAPK

• Hoofdauteurs: Yuanyue Jiang (Auteur), Yanfei Fang (Auteur), Yang Ye (Auteur), Xinming Xu (Auteur), Bingfang Wang (Auteur), Jie Gu (Auteur), Michael Aschner (Auteur), Jian Chen (Auteur), Rongzhu Lu (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2019-10-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Purpose: 3,3'-Diindolylmethane (DIM), derived from indole-3-carbinol (I3C) in the Brassica species of cruciferous vegetables, has anticancer effects, but its exact underlying mechanism of action is unknown. We explored the roles of cytosolic free calcium ([Ca2+]i) and p38 MAPK in the anti-cance...