Strong Inhibitory Effect, Low Cytotoxicity and High Plasma Stability of Steroidal Inhibitors of N-Methyl-D-Aspartate Receptors With C-3 Amide Structural Motif

• Main Authors: Santosh Kumar Adla (Author), Barbora Slavikova (Author), Hana Chodounska (Author), Vojtech Vyklicky (Author), Marek Ladislav (Author), Pavla Hubalkova (Author), Barbora Krausova (Author), Tereza Smejkalova (Author), Michaela Nekardova (Author), Marketa Smidkova (Author), Lenka Monincova (Author), Radko Soucek (Author), Ladislav Vyklicky (Author), Eva Kudova (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Herein, we report the synthesis, structure-activity relationship study, and biological evaluation of neurosteroid inhibitors of N-methyl-D-aspartate receptors (NMDARs) receptors that employ an amide structural motif, relative to pregnanolone glutamate (PAG) - a compound with neuroprotective properti...