TLR7 activation in M-CSF-dependent monocyte-derived human macrophages potentiates inflammatory responses and prompts neutrophil recruitment

• 主要な著者: Miriam Simón-Fuentes (著者), Cristina Herrero (著者), Lucia Acero-Riaguas (著者), Concha Nieto (著者), Fatima Lasala (著者), Nuria Labiod (著者), Joanna Luczkowiak (著者), Bárbara Alonso (著者), Rafael Delgado (著者), Maria Colmenares (著者), Ángel L. Corbí (著者), Ángeles Domínguez-Soto (著者)
• フォーマット: 図書
• 出版事項: Karger Publishers, 2023-04-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Toll-like receptor 7 (TLR7) is an endosomal Pathogen-Associated Molecular Pattern (PAMP) receptor that senses single-stranded RNA (ssRNA) and whose engagement results in the production of type I IFN and pro-inflammatory cytokines upon viral exposure. Recent genetic studies have established that a dy...