TLR7 activation in M-CSF-dependent monocyte-derived human macrophages potentiates inflammatory responses and prompts neutrophil recruitment

• Main Authors: Miriam Simón-Fuentes (Author), Cristina Herrero (Author), Lucia Acero-Riaguas (Author), Concha Nieto (Author), Fatima Lasala (Author), Nuria Labiod (Author), Joanna Luczkowiak (Author), Bárbara Alonso (Author), Rafael Delgado (Author), Maria Colmenares (Author), Ángel L. Corbí (Author), Ángeles Domínguez-Soto (Author)
• Format: Book
• Published: Karger Publishers, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Toll-like receptor 7 (TLR7) is an endosomal Pathogen-Associated Molecular Pattern (PAMP) receptor that senses single-stranded RNA (ssRNA) and whose engagement results in the production of type I IFN and pro-inflammatory cytokines upon viral exposure. Recent genetic studies have established that a dy...