Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: Water Channel Aquaporin-2 of Kidney Collecting Duct Cells

• Main Authors: Kuniaki Takata (Author), Yuki Tajika (Author), Toshiyuki Matsuzaki (Author), Takeo Aoki (Author), Takeshi Suzuki (Author), Ablimit Abduxukur (Author), Haruo Hagiwara (Author)
• Format: Book
• Published: Elsevier, 2004-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aquaporin-2 (AQP2) is one of the membrane water channel proteins expressed in principal cells of the kidney collecting ducts. In the basal state, AQP2 resides in the storage vesicles localized in the subapical cytoplasm. Upon stimulation with vasopressin, AQP2 is translocated to the apical plasma me...