Immunisation with a multivalent, subunit vaccine reduces patent infection in a natural bovine model of onchocerciasis during intense field exposure.

• Main Authors: Benjamin L Makepeace (Author), Siv Aina Jensen (Author), Sandra J Laney (Author), Charles K Nfon (Author), Leo M Njongmeta (Author), Vincent N Tanya (Author), Steven A Williams (Author), Albert E Bianco (Author), Alexander J Trees (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human onchocerciasis, caused by the filarial nematode Onchocerca volvulus, is controlled almost exclusively by the drug ivermectin, which prevents pathology by targeting the microfilariae. However, this reliance on a single control tool has led to interest in vaccination as a potentially complementa...