Cocaine Reduces the Neuronal Population While Upregulating Dopamine D2-Receptor-Expressing Neurons in Brain Reward Regions: Sex-Effects

• Main Authors: Kevin Clare (Author), Chelsea Pan (Author), Gloria Kim (Author), Kicheon Park (Author), Juan Zhao (Author), Nora D. Volkow (Author), Zhicheng Lin (Author), Congwu Du (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Addiction to cocaine is associated with dysfunction of the dopamine mesocortical system including impaired dopamine-2 receptor (D2r) signaling. However, the effects of chronic cocaine on neuronal adaptations in this system have not been systematically examined and data available is mostly from males...