Design, Synthesis, and Development of Pyrazolo[1,5-<i>a</i>]pyrimidine Derivatives as a Novel Series of Selective PI3K<i>δ</i> Inhibitors: Part II-Benzimidazole Derivatives

• Main Authors: Mariola Stypik (Author), Stanisław Michałek (Author), Nina Orłowska (Author), Marcin Zagozda (Author), Maciej Dziachan (Author), Martyna Banach (Author), Paweł Turowski (Author), Paweł Gunerka (Author), Daria Zdżalik-Bielecka (Author), Aleksandra Stańczak (Author), Urszula Kędzierska (Author), Krzysztof Mulewski (Author), Damian Smuga (Author), Wioleta Maruszak (Author), Lidia Gurba-Bryśkiewicz (Author), Arkadiusz Leniak (Author), Wojciech Pietruś (Author), Zbigniew Ochal (Author), Mateusz Mach (Author), Beata Zygmunt (Author), Jerzy Pieczykolan (Author), Krzysztof Dubiel (Author), Maciej Wieczorek (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Phosphoinositide 3-kinase (PI3K) is the family of lipid kinases participating in vital cellular processes such as cell proliferation, growth, migration, or cytokines production. Due to the high expression of these proteins in many human cells and their involvement in metabolism regulation, normal em...