Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors

• Main Authors: Moataz A. Shaldam (Author), Hadia Almahli (Author), Andrea Angeli (Author), Rehab Mustafa Badi (Author), Eman F. Khaleel (Author), Abdelrahman I. Zain-Alabdeen (Author), Zainab M. Elsayed (Author), Eslam B. Elkaeed (Author), Rofaida Salem (Author), Claudiu T. Supuran (Author), Wagdy M. Eldehna (Author), Haytham O. Tawfik (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this work, new isatin-based sulphonamides (6a-i, 11a-c, 12a-c) were designed and synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer activities. Firstly, all target isatins were examined for in vitro antitumor action on NCI-USA panel (58 tumour cell lines). The...