Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors

• Autori principali: Moataz A. Shaldam (Autore), Hadia Almahli (Autore), Andrea Angeli (Autore), Rehab Mustafa Badi (Autore), Eman F. Khaleel (Autore), Abdelrahman I. Zain-Alabdeen (Autore), Zainab M. Elsayed (Autore), Eslam B. Elkaeed (Autore), Rofaida Salem (Autore), Claudiu T. Supuran (Autore), Wagdy M. Eldehna (Autore), Haytham O. Tawfik (Autore)
• Natura: Libro
• Pubblicazione: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

In this work, new isatin-based sulphonamides (6a-i, 11a-c, 12a-c) were designed and synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer activities. Firstly, all target isatins were examined for in vitro antitumor action on NCI-USA panel (58 tumour cell lines). The...