Molecular basis of rare aminoglycoside susceptibility and pathogenesis of Burkholderia pseudomallei clinical isolates from Thailand.

• Main Authors: Lily A Trunck (Author), Katie L Propst (Author), Vanaporn Wuthiekanun (Author), Apichai Tuanyok (Author), Stephen M Beckstrom-Sternberg (Author), James S Beckstrom-Sternberg (Author), Sharon J Peacock (Author), Paul Keim (Author), Steven W Dow (Author), Herbert P Schweizer (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2009-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Burkholderia pseudomallei is intrinsically resistant to aminoglycosides and macrolides, mostly due to AmrAB-OprA efflux pump expression. We investigated the molecular mechanisms of aminoglycoside susceptibility exhibited by Thai strains 708a, 2188a, and 3799a.qRT-PCR revealed absence of amrB transcr...