Novel drug transporter substrates identification: An innovative approach based on metabolomic profiling, in silico ligand screening and biological validation

• Main Authors: Anne T. Nies (Author), Jörg König (Author), Patrick Leuthold (Author), Katja Damme (Author), Stefan Winter (Author), Mathias Haag (Author), Satohiro Masuda (Author), Stephan Kruck (Author), Hannelore Daniel (Author), Britta Spanier (Author), Martin F. Fromm (Author), Jens Bedke (Author), Ken-ichi Inui (Author), Matthias Schwab (Author), Elke Schaeffeler (Author)
• Format: Book
• Published: Elsevier, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Solute carrier (SLC) transport proteins are fundamental for the translocation of endogenous compounds and drugs across membranes, thus playing a critical role in disease susceptibility and drug response. Because only a limited number of transporter substrates are currently known, the function of a l...