Lactate-Loaded Nanoparticles Induce Glioma Cytotoxicity and Increase the Survival of Rats Bearing Malignant Glioma Brain Tumor

• Main Authors: Víctor Chavarria (Author), Emma Ortiz-Islas (Author), Alelí Salazar (Author), Verónica Pérez-de la Cruz (Author), Alejandra Espinosa-Bonilla (Author), Rubén Figueroa (Author), Alma Ortíz-Plata (Author), Julio Sotelo (Author), Francisco Javier Sánchez-García (Author), Benjamín Pineda (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A glioblastoma is an aggressive form of a malignant glial-derived tumor with a poor prognosis despite multimodal therapy approaches. Lactate has a preponderant role in the tumor microenvironment, playing an immunoregulatory role as well as being a carbon source for tumor growth. Lactate homeostasis...