Application of a physiologically based pharmacokinetic model to predict isoniazid disposition during pregnancy
Abstract Pregnancy can increase the risk of latent tuberculosis infection (LTBI) progression to tuberculosis (TB) disease. Isoniazid (INH) is the preferred preventative treatment for LTBI in pregnancy. INH is mainly cleared by N‐acetyltransferase 2 (NAT2) but the pharmacokinetics (PK) of INH in diff...
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Wiley,
2023-11-01T00:00:00Z.
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