Two Novel Co-Crystals of Naproxen: Comparison of Stability, Solubility and Intermolecular Interaction

• Main Authors: Cheng Xing (Author), Ting Chen (Author), Li Wang (Author), Qi An (Author), Yali Jin (Author), Dezhi Yang (Author), Li Zhang (Author), Guanhua Du (Author), Yang Lu (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Two novel co-crystals of naproxen (NPX) were designed and prepared at a stoichiometric ratio of 1:1, namely, naproxen-caprolactam (NPX-CPL) and naproxen-oxymatrine (NPX-OMT). The characteristics of the co-crystals were evaluated in terms of stability and solubility studies. In terms of solubility, i...