The Protective Effect of Silibinin Against Mitomycin C-Induced Intrinsic Apoptosis in Human Melanoma A375-S2 Cells

• Main Authors: Yuan-yuan Jiang (Author), Hong-jun Wang (Author), Jing Wang (Author), Shin-ichi Tashiro (Author), Satoshi Onodera (Author), Takashi Ikejima (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Silibinin is known for its hepatoprotective, anti-inflammatory, and anti-carcinogenic effects. We found that silibinin exhibited a protective effect against chemotherapeutic reagent mitomycin C-induced cell death in A375-S2 cells in a p53-dependent manner, which contradicted the findings of previous...