Solution structure of a repeated unit of the ABA-1 nematode polyprotein allergen of Ascaris reveals a novel fold and two discrete lipid-binding sites.

• Main Authors: Nicola A G Meenan (Author), Graeme Ball (Author), Krystyna Bromek (Author), Dušan Uhrín (Author), Alan Cooper (Author), Malcolm W Kennedy (Author), Brian O Smith (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nematode polyprotein allergens (NPAs) are an unusual class of lipid-binding proteins found only in nematodes. They are synthesized as large, tandemly repetitive polyproteins that are post-translationally cleaved into multiple copies of small lipid binding proteins with virtually identical fatty acid...