Prediction of Metabolite‐to‐Parent Drug Exposure: Derivation and Application of a Mechanistic Static Model

• मुख्य लेखकों: Ernesto Callegari (लेखक), Manthena V.S. Varma (लेखक), R. Scott Obach (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2020-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

In the development of new drugs, the prediction of metabolite‐to‐parent plasma exposure ratio in humans prior to administration in a clinical study has emerged as an important need. In this work, we derived a mechanistic static model based on first principles to estimate metabolite‐to‐parent plasma...