Statins mediate anti- and pro-tumourigenic functions by remodelling the tumour microenvironment

• Main Authors: Tamihiro Kamata (Author), Esraa Al Dujaily (Author), Salwa Alhamad (Author), Tsz Y. So (Author), Olga Margaritaki (Author), Susan Giblett (Author), J. Howard Pringle (Author), John Le Quesne (Author), Catrin Pritchard (Author)
• Format: Book
• Published: The Company of Biologists, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Anti-cancer properties of statins are controversial and possibly context dependent. Recent pathology/epidemiology studies of human lung adenocarcinoma showed reduced pro-tumourigenic macrophages associated with a shift to lower-grade tumours amongst statin users but, paradoxically, worse survival co...