The activation of the G-protein-coupled estrogen receptor promotes the aggressiveness of MDA-MB231 cells by targeting the IRE1α/TXNIP pathway

• Main Authors: Maryam Mohammad-Sadeghipour (Author), Mohammad Hadi Nematollahi (Author), Hassan Ahmadinia (Author), Mohammad Reza Hajizadeh (Author), Mehdi Mahmoodi (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and purpose: This study investigated modulating the G protein-coupled estrogen receptor (GPER) on the IRElα/TXNIP pathway and its role in drug resistance in MDA-MB231 cells. Experimental approach: To determine the optimal concentrations of G1 and 4-hydroxytamoxifen (TAM), GPER expression...