Deletion of a single allele of the Pex11β gene is sufficient to cause oxidative stress, delayed differentiation and neuronal death in mouse brain

• Päätekijät: Barbara Ahlemeyer (Tekijä), Magdalena Gottwald (Tekijä), Eveline Baumgart-Vogt (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: The Company of Biologists, 2012-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

SUMMARY Impaired neuronal migration and cell death are commonly observed in patients with peroxisomal biogenesis disorders (PBDs), and in mouse models of this diseases. In Pex11β-deficient mice, we observed that the deletion of a single allele of the Pex11β gene (Pex11β+/− heterozygous mice) caused...