Indoxyl sulfate aggravates podocyte damage through the TGF-β1/Smad/ROS signaling pathway

• Main Authors: Miao Jia (Author), Lihua Lin (Author), Kang Xun (Author), Damei Li (Author), Weijiang Wu (Author), Shaobo Sun (Author), Hong Qiu (Author), Donghua Jin (Author)
• Format: Book
• Published: Karger Publishers, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Hyperglycaemia induces the production of a large quantity of reactive oxygen species (ROS) and activates the transforming growth factor β1(TGF-β1)/Smad signalling pathway, which is the main initiating factor in the formation of diabetic nephropathy. Indoxyl sulfate (IS) is a protein-bi...