Nivolumab use for BRCA gene mutation carriers with recurrent epithelial ovarian cancer: A case series

• Main Authors: Koji Matsuo (Author), Samantha E. Spragg (Author), Marcia A. Ciccone (Author), Erin A. Blake (Author), Charité Ricker (Author), Huyen Q. Pham (Author), Lynda D. Roman (Author)
• Format: Book
• Published: Elsevier, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tumors deficient in DNA mismatch repair are known to display increased susceptibility to immune checkpoint inhibitors due to accumulation of DNA damage and increased neoantigen load. This suggests that deficiency in the BRCA-related DNA repair mechanism may also be a surrogate marker for immunothera...