High cyclin E1 protein, but not gene amplification, is prognostic for basal‐like breast cancer

• Main Authors: Diar Aziz (Author), Christine Lee (Author), Venessa Chin (Author), Kristine J Fernandez (Author), Zoe Phan (Author), kConFab Investigators (Author), AOCS Study Group (Author), Paul Waring (Author), C Elizabeth Caldon (Author)
• Format: Book
• Published: Wiley, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Basal‐like breast cancer (BLBC) has a greater overlap in molecular features with high‐grade serous ovarian cancer (HGSOC) than with other breast cancer subtypes. Similarities include BRCA1 mutation, high frequency of TP53 mutation, and amplification of CCNE1 (encoding the cyclin E1 protein)...