MHC-I alleles mediate clearance and antibody response to the zoonotic Lassa virus in Mastomys rodent reservoirs.

• Main Authors: Ayodeji Olayemi (Author), Dominik Werner Schmid (Author), Ramona Fleischer (Author), Kerstin Wilhelm (Author), Alexander Christoph Heni (Author), Nadine Mueller-Klein (Author), Lavinia Haikukutu (Author), Elisabeth Fichet-Calvet (Author), Stephan Günther (Author), Simone Sommer (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

West African Mastomys rodents are the primary reservoir of the zoonotic Lassa virus (LASV). The virus causes haemorrhagic Lassa fever and considerable mortality in humans. To date, the role of Mastomys immunogenetics in resistance to, and persistence of, LASV infections is largely unknown. Here, we...