A New Transferrin Receptor Aptamer Inhibits New World Hemorrhagic Fever Mammarenavirus Entry

• Main Authors: Keith E Maier (Author), Rohit K Jangra (Author), Kevin R Shieh (Author), David K Cureton (Author), Hui Xiao (Author), Erik L Snapp (Author), Sean P Whelan (Author), Kartik Chandran (Author), Matthew Levy (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pathogenic New World hemorrhagic fever mammarenaviruses (NWM) utilize Glycoprotein 1 (GP1) to target the apical domain of the human transferrin receptor (hTfR) for facilitating cell entry. However, the conservation between their GP1s is low. Considering this and the slow evolutionary progression of...