Adenosine Kinase of T. b. Rhodesiense identified as the putative target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine using chemical proteomics.

• Главные авторы: Sabine Kuettel (Автор), Marc Mosimann (Автор), Pascal Mäser (Автор), Marcel Kaiser (Автор), Reto Brun (Автор), Leonardo Scapozza (Автор), Remo Perozzo (Автор)
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• Опубликовано: Public Library of Science (PLoS), 2009-01-01T00:00:00Z.
• Предметы: article
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BACKGROUND: Human African trypanosomiasis (HAT), a major parasitic disease spread in Africa, urgently needs novel targets and new efficacious chemotherapeutic agents. Recently, we discovered that 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine (compound 1) exhibits specific antitrypanosomal activi...