Alpha1-antitrypsin ameliorates islet amyloid-induced glucose intolerance and β-cell dysfunction

• Váldodahkkit: Júlia Rodríguez-Comas (Dahkki), Juan Moreno-Vedia (Dahkki), Mercè Obach (Dahkki), Carlos Castaño (Dahkki), Sara de Pablo (Dahkki), Gema Alcarraz-Vizán (Dahkki), Daniela Díaz-Catalán (Dahkki), Anna Mestre (Dahkki), Raquel Horrillo (Dahkki), Montserrat Costa (Dahkki), Anna Novials (Dahkki), Joan-Marc Servitja (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2020-07-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Objective: Pancreatic β-cell failure is central to the development and progression of type 2 diabetes (T2D). The aggregation of human islet amyloid polypeptide (hIAPP) has been associated with pancreatic islet inflammation and dysfunction in T2D. Alpha1-antitrypsin (AAT) is a circulating protease in...