Alpha1-antitrypsin ameliorates islet amyloid-induced glucose intolerance and β-cell dysfunction

• Main Authors: Júlia Rodríguez-Comas (Author), Juan Moreno-Vedia (Author), Mercè Obach (Author), Carlos Castaño (Author), Sara de Pablo (Author), Gema Alcarraz-Vizán (Author), Daniela Díaz-Catalán (Author), Anna Mestre (Author), Raquel Horrillo (Author), Montserrat Costa (Author), Anna Novials (Author), Joan-Marc Servitja (Author)
• Format: Book
• Published: Elsevier, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Pancreatic β-cell failure is central to the development and progression of type 2 diabetes (T2D). The aggregation of human islet amyloid polypeptide (hIAPP) has been associated with pancreatic islet inflammation and dysfunction in T2D. Alpha1-antitrypsin (AAT) is a circulating protease in...