Alpha1-antitrypsin ameliorates islet amyloid-induced glucose intolerance and β-cell dysfunction

• Autors principals: Júlia Rodríguez-Comas (Autor), Juan Moreno-Vedia (Autor), Mercè Obach (Autor), Carlos Castaño (Autor), Sara de Pablo (Autor), Gema Alcarraz-Vizán (Autor), Daniela Díaz-Catalán (Autor), Anna Mestre (Autor), Raquel Horrillo (Autor), Montserrat Costa (Autor), Anna Novials (Autor), Joan-Marc Servitja (Autor)
• Format: Llibre
• Publicat: Elsevier, 2020-07-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Objective: Pancreatic β-cell failure is central to the development and progression of type 2 diabetes (T2D). The aggregation of human islet amyloid polypeptide (hIAPP) has been associated with pancreatic islet inflammation and dysfunction in T2D. Alpha1-antitrypsin (AAT) is a circulating protease in...