Involvement of 5-HT2A receptor hyperfunction in the anxiety-like behavior induced by doxorubicin and cyclophosphamide combination treatment in rats

• Main Authors: Yuka Nakamura (Author), Yoshihisa Kitamura (Author), Yusuke Sumiyoshi (Author), Nanami Naito (Author), Shiho Kan (Author), Soichiro Ushio (Author), Ikuko Miyazaki (Author), Masato Asanuma (Author), Toshiaki Sendo (Author)
• Format: Book
• Published: Elsevier, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We examined whether combination treatment with doxorubicin and cyclophosphamide, a traditional chemotherapy for breast cancer, induced anxiety-like behavior in rats. Furthermore, we evaluated the role of the serotonin (5-HT)2A receptor subtype in the anxiety-like behavior induced by such chemotherap...