Screening of Hydrocarbon-Stapled Peptides for Inhibition of Calcium-Triggered Exocytosis

• Ngā kaituhi matua: Ying Lai (Author), Michael J. Tuvim (Author), Jeremy Leitz (Author), John Peters (Author), Richard A. Pfuetzner (Author), Luis Esquivies (Author), Qiangjun Zhou (Author), Barbara Czako (Author), Jason B. Cross (Author), Philip Jones (Author), Burton F. Dickey (Author), Axel T. Brunger (Author)
• Hōputu: Pukapuka
• I whakaputaina: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

The so-called primary interface between the SNARE complex and synaptotagmin-1 (Syt1) is essential for Ca2+-triggered neurotransmitter release in neuronal synapses. The interacting residues of the primary interface are conserved across different species for synaptotagmins (Syt1, Syt2, Syt9), SNAP-25,...