Screening of Hydrocarbon-Stapled Peptides for Inhibition of Calcium-Triggered Exocytosis

• Main Authors: Ying Lai (Author), Michael J. Tuvim (Author), Jeremy Leitz (Author), John Peters (Author), Richard A. Pfuetzner (Author), Luis Esquivies (Author), Qiangjun Zhou (Author), Barbara Czako (Author), Jason B. Cross (Author), Philip Jones (Author), Burton F. Dickey (Author), Axel T. Brunger (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The so-called primary interface between the SNARE complex and synaptotagmin-1 (Syt1) is essential for Ca2+-triggered neurotransmitter release in neuronal synapses. The interacting residues of the primary interface are conserved across different species for synaptotagmins (Syt1, Syt2, Syt9), SNAP-25,...