1-Oxo-3,4-dihydroisoquinoline-4-carboxamides as novel druglike inhibitors of poly(ADP-ribose) polymerase (PARP) with favourable ADME characteristics

• Автори: Alexander Safrygin (Автор), Petr Zhmurov (Автор), Dmitry Dar'in (Автор), Sergey Silonov (Автор), Mariia Kasatkina (Автор), Yulia Zonis (Автор), Maxim Gureev (Автор), Mikhail Krasavin (Автор)
• Формат: Книга
• Опубліковано: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

A novel 3,4-dihydroisoquinol-1-one-4-carboxamide scaffold was designed as the basis for the development of novel inhibitors of poly(ADP-ribose) polymerase (PARP). Synthesis of 3,4-dihydroisoquinol-1-one-4-carboxylic acids was achieved using the previously developed protocol based on the modified Cas...